PD Cognitive Cascade Staging Calculator

Research Tool Only. This calculator is for research and educational purposes. It is based on population-level models from the PPMI cohort and should not be used for individual clinical decision-making without physician oversight. See: Negida A. Temporal Ordering of Biomarker Abnormality Events Leading to Cognitive Impairment in Parkinson's Disease.

M Motor Assessment

MDS-UPDRS Part IIITotal score, best state (0–132)

G Global Cognition

MoCA Total ScoreRaw score (0–30)

N Neuropsychiatric Symptoms

Depression (UPDRS I, 1.3)0 = Normal, 4 = Severe

Apathy (UPDRS I, 1.4)0 = Normal, 4 = Severe

Cognitive Complaints (UPDRS I, 1.1)0 = Normal, 4 = Severe

A Autonomic & Sleep

SCOPA-AUT TotalAutonomic symptoms (0–69)

RBDSQ TotalRBD screening (0–13)

C Domain-Specific Cognitive Scores (Demographically Corrected)

HVLT-R Total RecallT-score (mean=50, SD=10)

HVLT-R Delayed RecallT-score (mean=50, SD=10)

Letter-Number Seq.Scaled score (mean=10, SD=3)

Symbol Digit Mod.T-score (mean=50, SD=10)

Semantic FluencyT-score (mean=50, SD=10)

Judgment of Line Orient.Scaled score (mean=10, SD=3)